Tollovid Q&A with Todos Medical

Tollovid Q&A with Todos Medical

1. Does Tollovid prevent viral replication systemically? Does it cross Blood Brain Barrier?

Our belief and observations are that it inhibits the 3CL protease systemically. We do not have BBB studies, however in instances with high 3CL content it is expected the BBB is “leaky” any many things get through. We have seen symptomatic benefits associated with reduction in 3CLpro in the brain, but cannot confirm this without radioactive co-location studies which are not really the best ways to go in this patient population, so we are relying on symptomatic benefit.

2. Has Tollovid been tested with COVID Long Haulers or acute patients? 

Tollovid has primarily been used to date in an acute setting of high 3CLpro content, however we are now seeing it used in cases of persistent 3CLpro content. We expect it to eliminate 3CLpro in either circumstance.

3. Is Tollovid considered similar to Paxlovid and thus a good option if you can’t get that when you have acute COVID?

The mechanism of action of Tollovid is the same as Paxlovid (although we target the receptor binding domain of the 3CLpro – the active site, whereas Pfizer does not).

4. Can Tollovid be taken long term? If it can be, how long and at what dose? Any toxicity or side effects with it? 

We have not observed any side effects with long term use of Tollovid, however we do not have formal studies so cannot confirm this. We have not found side effects other than soy allergy to the soy lecithin in the product.

5. What’s the difference in the Tollovid Daily and Max?

Max has much greater 3CLpro inhibition capabilities than Daily … approximately 5-10x stronger.

6. Any issue using Tollovid long term in terms of a reduction in effectiveness against COVID?

Doubtful that 3CLpro will mutate given the target is a derivative of SARS-CoV-2, and therefore no evolutionary pressures on it. This target has not mutated and is deemed ‘canonical’ because it appears variant. The biggest mutation risk is likely Molnupiravir.

7. Does Tollovid work on other viruses? Would it help with EBV, Herpes, etc.?

It inhibits the 3CLpro. You can see the areas in which 3CLpro is present. You can scroll down to the subviruses associated with it. Including Nidoviruses, Picornaviruses, and Caliciviridae.

https://en.wikipedia.org/wiki/3C-like_protease

8. Do you think taking Tollovid after a course of Paxlovid makes sense to combat the rebound effect many. myself included, face?

That may make sense as it appears there is sometimes significant residual 3CLpro following Paxlovid.

9. Are there any contraindications with Tollovid? 

None that I’m aware of.

10. Does Tollovid change the color of your stool (does it make it darker or black)? 

Yes, it makes the stool darker by virtue of the Gromwell Root. This is completely normal and no side effect. Gromwell is also used as a natural purple colorant.

11. What is the difference between Tollovid and Tollovir?

The 3CL protease inhibition mechanism is the same in all three [including Paxlovid] (although Tollovir and Tollovid target the active site of the 3CLpro). Tollovir has an enhanced key anti-cytokine/anti-inflammatory component that very much differentiates it from Tollovid/Paxlovid.

12. Have you noticed people having Herxheimer reactions to Tollovid? 

We haven’t had that specific diagnosis, but have heard of people having an initial ‘reaction’ that subsides within 24h followed by benefit. We are looking into this further.

13. What’s the recommended dose for Acute COVID and Long Haulers with COVID? 

The recommended acute dose (Tollovid Max 3 pill 4x a day) is recommended for people looking to dramatically reduce their 3CL pro content. How long someone has had 3CLpro in their system may be different than ‘how much’ and ‘where’ so we recommend going with the Max dosing to start and then based upon resolution transitioning (at whatever pace a person feels right for them) to the maintenance dose. 

14. People in Europe are asking me if and how they can get this. How can non Americans get Tollovid?

People have been ordering from Europe, and it gets through customs. Often, they charge a local duty based on the commercial invoice. Hope this helps.

Tollovid aka CovidRid?

Tollovid aka CovidRid?

Yes, the title for this article is lame, but don’t worry I know it is lame, so it’s ok. With that being said, for almost 3 weeks I’ve been on Tollovid. I’ve had a significant shift in my health for the better, but it’s not that simple. It never is. As I reduce the dose I’ve felt what seems like a rebound effect, which has been seen in some who take Paxlovid. (https://www.cnn.com/2022/05/10/opinions/paxlovid-rebound-covid-treatment-sepkowitz/index.html) It’s something similar to what I also have experienced with Paxlovid and Monoclonal Antibodies, Paxlovid especially. It’s not a negative in my mind, but it’s brought on some different symptoms that I haven’t experienced so strongly in a while. I’m going to provide more detail about all this, and what this rebound feels like below, but first let me explain what Tollovid is for those who don’t know.

Tollovid is a supplement made by Todos Medical. It’s main components are Gromwell Root and Lecithin. It is a 3CL protease inhibitor, similar to Paxlovid, thus it acts as an antiviral agent by stopping replication of SARS-CoV-2, and other Coronaviruses. It also helps with inflammation, circulation, and detoxification, amongst other things, but the 3CL protease inhibitor aspect is the most intriguing to me.

My Tollovid journey started about 20 days ago. For the first 14 days I took Tollovid Max 4x a day 3 pills at a time. That is the maximum dose and they suggest to take that for 5 days straight (seems to be the dosage used for those in an acute situation, but I am a COVID Long Hauler). This went very well. I have more brain power, energy, was in a better mood, and was much more active. My inflammation in my torso in particular decreased and my urine color changed for the better and stool became more normalized. The symptoms I had at the time were mitigated a lot. On top of that, I’ve also been coughing up a lot of phlegm. The Tollovid really kicked in in a couple of days and the noticed benefits continued. During this period I was amazing inspired to go through all my stuff, which was a lot, to organize and get rid of things. This was never a thought before taking Tollovid.

On to Phase 2, finding the correct reduced dose for me. I’m still in this phase and it’s complicated, and interesting. Day 15 I decided to drop to the recommended maintenance dose of 2 pills 2x a day which is 33% of the max dose. With this change I experienced what felt like a rebound, very similar to what I experienced the first day coming off of Paxlovid after taking it for 5 days straight. My symptoms shifted and came on strong, up and down throughout the day. With Paxlovid, I had a wild nervous system reaction, increased blood pressure, and had a very tough time for about 2 days, until it gradually dissipated after 7 days. The next few days, after day 15, I increased my dose to 3 pills 2x a day, 2-2-3 pills in a day, and now the past several days I’ve done 3 pills 3x a day, which seems to be working well for me for now. The symptoms I experienced were/are increased inflammation in the head (headaches, pain on side of head), chest, heart, nerves (extra weakness at times, some pins and needles), and joints in particular all worse from the baseline from before I started the Tollovid, but with a big up and down swing throughout the day. It was certainly not as severe as going off Paxlovid cold turkey and it is better now on day 20. The spots affected were the hot spots from the past 2 plus years with COVID, but weren’t exactly the main issues I had when I started the supplement. Phase 3 is how long do I have to take this for and what will be the true maintenance dose.

With Monoclonal Antibodies, which I used for my Long Haul COVID, the symptoms I was experiencing at the time quickly improved, two of which were chest inflammation and joint pain. My neuro symptoms came on strong for about a month, up and down (more up and down than normal). With Paxlovid, used for an Acute COVID Reinfection (and Long Haul COVID), it took away my chest inflammation very fast and helped with the acute symptoms overall. The day I came off I had an extreme rebound effect, that I explained above. That first day off was really difficult to get through. I basically went back to my Long Haul (LH) baseline, with a tiny bit of improvement in my LH, after a week off of the Paxlovid. With the Tollovid, my Long Haul COVID symptoms at the time were also helped quickly and continued to improve while taking the max dose. Once I reduced the dose, I felt what I assume was that dreaded rebound effect. Symptoms shifted and they increased in intensity from where they were baseline with a big up and down swing. They all acted similarly, but they don’t all do the same things, except for one thing that they do.

So what’s happening here? I believe all three of these things were working on persistent COVID-19 virus. What else explains these similar reactions? What is the cross-over between these 3 things other than they are working against the virus? mAbs are an infusion of antibodies which will help combat the virus. Paxlovid and Tollovid are 3CL protease inhibitors which prevent viral replication. Tollovid has various benefits, but do the other 2 have various benefits? To me this screams persistent virus, which I have believed all along. It’s hard to figure out exactly why I’ve had these reactions, meaning what is actually going on in the body to get that rebound, increased inflammation effect, but it is not uncommon with other viruses and medications. Tollovid does seem to give me a little herx right after I take it, another indication I have persistent virus. A herx is a die off reaction by the way. In the very least to me it indicates Covid can persist in some, and may be a big reason for Long Haul Covid. I’ll continue to take Tollovid and provide an update in the future.


UPDATE – 7/30/23

Still taking Tollovid to this day. I’ve settled on 3 pills 2x day, but when I’m running low I take 3 pills 1x a day, and even that helps me. I can notice when I have increased symptoms that after taking Tollovid they will reduce in short time. If I don’t take Tollovid for a period, symptoms will increase (not as much as they used to). I’m much more functional now and currently on an RV trip creating a docuseries called “Castaways.” Tollovid expensive, but at a maintenance dose it’s manageable, and for me it’s a very valuable part of my regiment. I wouldn’t say it’s a CovidRid, but it’s very much helping with what I assume is persistent COVID and with coinfections I’m quite confident I’ve had.