Tollovid Q&A with Todos Medical
1. Does Tollovid prevent viral replication systemically? Does it cross Blood Brain Barrier?
Our belief and observations are that it inhibits the 3CL protease systemically. We do not have BBB studies, however in instances with high 3CL content it is expected the BBB is “leaky” any many things get through. We have seen symptomatic benefits associated with reduction in 3CLpro in the brain, but cannot confirm this without radioactive co-location studies which are not really the best ways to go in this patient population, so we are relying on symptomatic benefit.
2. Has Tollovid been tested with COVID Long Haulers or acute patients?
Tollovid has primarily been used to date in an acute setting of high 3CLpro content, however we are now seeing it used in cases of persistent 3CLpro content. We expect it to eliminate 3CLpro in either circumstance.
3. Is Tollovid considered similar to Paxlovid and thus a good option if you can’t get that when you have acute COVID?
The mechanism of action of Tollovid is the same as Paxlovid (although we target the receptor binding domain of the 3CLpro – the active site, whereas Pfizer does not).
4. Can Tollovid be taken long term? If it can be, how long and at what dose? Any toxicity or side effects with it?
We have not observed any side effects with long term use of Tollovid, however we do not have formal studies so cannot confirm this. We have not found side effects other than soy allergy to the soy lecithin in the product.
5. What’s the difference in the Tollovid Daily and Max?
Max has much greater 3CLpro inhibition capabilities than Daily … approximately 5-10x stronger.
6. Any issue using Tollovid long term in terms of a reduction in effectiveness against COVID?
Doubtful that 3CLpro will mutate given the target is a derivative of SARS-CoV-2, and therefore no evolutionary pressures on it. This target has not mutated and is deemed ‘canonical’ because it appears variant. The biggest mutation risk is likely Molnupiravir.
7. Does Tollovid work on other viruses? Would it help with EBV, Herpes, etc.?
It inhibits the 3CLpro. You can see the areas in which 3CLpro is present. You can scroll down to the subviruses associated with it. Including Nidoviruses, Picornaviruses, and Caliciviridae.
8. Do you think taking Tollovid after a course of Paxlovid makes sense to combat the rebound effect many. myself included, face?
That may make sense as it appears there is sometimes significant residual 3CLpro following Paxlovid.
9. Are there any contraindications with Tollovid?
None that I’m aware of.
10. Does Tollovid change the color of your stool (does it make it darker or black)?
Yes, it makes the stool darker by virtue of the Gromwell Root. This is completely normal and no side effect. Gromwell is also used as a natural purple colorant.
11. What is the difference between Tollovid and Tollovir?
The 3CL protease inhibition mechanism is the same in all three [including Paxlovid] (although Tollovir and Tollovid target the active site of the 3CLpro). Tollovir has an enhanced key anti-cytokine/anti-inflammatory component that very much differentiates it from Tollovid/Paxlovid.
12. Have you noticed people having Herxheimer reactions to Tollovid?
We haven’t had that specific diagnosis, but have heard of people having an initial ‘reaction’ that subsides within 24h followed by benefit. We are looking into this further.
13. What’s the recommended dose for Acute COVID and Long Haulers with COVID?
The recommended acute dose (Tollovid Max 3 pill 4x a day) is recommended for people looking to dramatically reduce their 3CL pro content. How long someone has had 3CLpro in their system may be different than ‘how much’ and ‘where’ so we recommend going with the Max dosing to start and then based upon resolution transitioning (at whatever pace a person feels right for them) to the maintenance dose.
14. People in Europe are asking me if and how they can get this. How can non Americans get Tollovid?
People have been ordering from Europe, and it gets through customs. Often, they charge a local duty based on the commercial invoice. Hope this helps.